Therapeutic Strategies for Mutant SPAST-Based Hereditary Spastic Paraplegia

Therapeutic Strategies for Mutant SPAST-Based Hereditary Spastic Paraplegia

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Mutations of the SPAST gene that encodes the microtubule-severing enzyme read more called spastin are the chief cause of Hereditary Spastic Paraplegia.Growing evidence indicates that pathogenic mutations functionally compromise the spastin protein and endow it with toxic gain-of-function properties.With each of these two factors potentially relevant to disease etiology, the present article discusses possible therapeutic strategies that may ameliorate symptoms grand love red heart reposado tequila in patients suffering from SPAST-based Hereditary Spastic Paraplegia, which is usually termed SPG4-HSP.